Immediate prophylaxis after tetanus prone injuries in patients not adequately vaccinated; whose immunisation status is not known w/ certainty & w/ severe deficiency in Ab production. Clinically manifest tetanus.
IMProphylaxis of tetanus prone wounds 250 IU. Dose may be increased to 500 IU in case of infected wounds where surgically appropriate treatment cannot be achieved w/in 24 hr, or deep or contaminated wounds w/ tissue damage & reduced oxygen supply as well as foreign body injury. Therapy of clinically manifesting tetanus Single doses of 3,000-6,000 IU.
Not to be administered into blood vessel (risk of shock). Individuals w/ IgA deficiency. Discontinue if allergic or anaphylactic type reactions occur. May interfere w/ some serological tests for RBCs eg, Coombs' test. Pregnancy & lactation. Childn.
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